Discrete Turing Patterns in Coupled Reaction Cells in a Cyclic Array
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43903030" target="_blank" >RIV/60461373:22340/16:43903030 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s11144-016-1004-y" target="_blank" >http://dx.doi.org/10.1007/s11144-016-1004-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11144-016-1004-y" target="_blank" >10.1007/s11144-016-1004-y</a>
Alternative languages
Result language
angličtina
Original language name
Discrete Turing Patterns in Coupled Reaction Cells in a Cyclic Array
Original language description
Our work is focused on experimental observation of nonuniform stationary states (discrete Turing patterns) in a cyclic coupled cell array with glycolytic oscillatory reaction. Mutual mass exchange between two stirred reaction cells is realized by using a peristaltic pump delivering reciprocally the reaction mixture in both directions. The cells are fed by solutions of yeast extract and D-glucose. The cyclic system is formed by the two cells and the tubing, connecting the cells, acting as additional two reactors because of a non-negligible transport time. Experiments are conducted under 45oC and 50oC to thermally activate positive and negative feedback loops of the enzyme phosphofructokinase and thus achieve conditions appropriate for occurrence of the patterns. Dynamical state in one cell of the ring is measured using UV-Vis spectrophotometer reading absorbance levels of adenosine pool together with NAD+ (260nm) and absorbance level of NADH (340 nm). We report transitions between uniform stationary states, nonuniform stationary states (discrete Turing patterns) and uniform oscillations. We also performed analysis of stability and bifurcations of stationary states in a model of four coupled cells in a cyclic array using a core kinetic model of glycolysis. By examining the space of relevant parameters, we found conditions for occurrence of discrete Turing patterns consistent with our experiments. Solution diagrams are used to display the stationary concentration of ADP as a function of the inhibition rate coefficient and to explain the mechanism by which the discrete Turing patterns occur.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-17367S" target="_blank" >GA15-17367S: Dynamics of complex reaction networks in enzyme reactors and photobioreactors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Reaction Kinetics Mechanisms and Catalysis
ISSN
1878-5190
e-ISSN
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Volume of the periodical
118
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
16
Pages from-to
99-114
UT code for WoS article
000376107700010
EID of the result in the Scopus database
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