The Combined Use of Imaging Approaches to Assess Drug Release from Multicomponent Solid Dispersions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F17%3A43913499" target="_blank" >RIV/60461373:22340/17:43913499 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s11095-016-2018-x" target="_blank" >http://dx.doi.org/10.1007/s11095-016-2018-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11095-016-2018-x" target="_blank" >10.1007/s11095-016-2018-x</a>
Alternative languages
Result language
angličtina
Original language name
The Combined Use of Imaging Approaches to Assess Drug Release from Multicomponent Solid Dispersions
Original language description
Purpose Imaging methods were used as tools to provide an understanding of phenomena that occur during dissolution experiments, and ultimately to select the best ratio of two polymers in a matrix in terms of enhancement of the dissolution rate and prevention of crystallization during dissolution. Methods Magnetic resonance imaging, ATR-FTIR spectroscopic imaging and Raman mapping have been used to study the release mechanism of a poorly water soluble drug, aprepitant, from multicomponent amorphous solid dispersions. Solid dispersions were prepared based on the combination of two selected polymers - Soluplus, as a solubilizer, and PVP, as a dissolution enhancer. Formulations were prepared in a ratio of Soluplus:PVP 1:10, 1:5, 1:3, and 1:1, in order to obtain favorable properties of the polymer carrier. Results The crystallization of aprepitant during dissolution has occurred to a varying degree in the polymer ratios 1:10, 1:5, and 1:3, but the increasing presence of Soluplus in the formulation delayed the onset of crystallization. The Soluplus:PVP 1:1 solid dispersion proved to be the best matrix studied, combining the abilities of both polymers in a synergistic manner. Conclusion Aprepitant dissolution rate has been significantly enhanced. This study highlights the benefits of combining imaging methods in order to understand the release process.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20402 - Chemical process engineering
Result continuities
Project
<a href="/en/project/NV16-34342A" target="_blank" >NV16-34342A: Multifunctional Nano-Clusters as a Drug Delivery System</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PHARMACEUTICAL RESEARCH
ISSN
0724-8741
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
990-1001
UT code for WoS article
000399164800008
EID of the result in the Scopus database
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