Optimization of excipients for pharmaceutical dosage forms prepared by FDM 3D-printing

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F17%3A43914054" target="_blank" >RIV/60461373:22340/17:43914054 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Optimization of excipients for pharmaceutical dosage forms prepared by FDM 3D-printing
Original language description
3D printing of tablet-shaped dosage forms is a novel approach in pharmaceutical formulation, since 2015 it has its first commercial application. This method presents new advantages in the area of personalized dosing - each printed product can be tailored to meet the needs of a specific patient. Fused Deposition Modeling, a commercially available 3D printing technology, employed in the presented work, utilizes solid filaments made of thermoplastic materials as feed. The filaments were produced by mixing biodegradable pharmaceutical polymers, additives (plasticizers, anticaking agents or disintegrants) and defined contents of model drugs, and subsequently processing the powder-based mixtures by Hot-melt extrusion. The main challenge of this process, as was also reported in relevant contemporary literature, is to achieve printability of the produced filaments ? their mechanical properties have meet the requirements of the 3D-printing technology. Therefore, this work focuses on the effects of various excipients on the overall printability of the mixture. Furthermore, pharmaceutically relevant characteristics, such as achieved drug content, structure and inner porosity of the filaments were analyzed and will be discussed.
Czech name
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Czech description
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Project
<a href="/en/project/GJ17-21696Y" target="_blank" >GJ17-21696Y: Towards the understanding of evaporation induced pattern formation of decanol droplets</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
PROCEEDINGS 44th International Conference of the Slovak Society of Chemical Engineering
ISBN
978-80-89597-58-1
ISSN
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e-ISSN
neuvedeno
Number of pages
1
Pages from-to
661
Publisher name
Slovak Society of Chemical Engineering
Place of publication
Bratislava
Event location
Demänovská dolina
Event date
May 22, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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