Virtual Prototyping and Parametric Design of 3D-Printed Tablets Based on the Solution of Inverse Problem

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F18%3A43915872" target="_blank" >RIV/60461373:22340/18:43915872 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1208%2Fs12249-018-1176-z" target="_blank" >https://link.springer.com/article/10.1208%2Fs12249-018-1176-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1208/s12249-018-1176-z" target="_blank" >10.1208/s12249-018-1176-z</a>

Result language

angličtina

Original language name

Virtual Prototyping and Parametric Design of 3D-Printed Tablets Based on the Solution of Inverse Problem

Original language description

The problem of designing tablet geometry and its internal structure that results into a specified release profile of the drug during dissolution was considered. A solution method based on parametric programming, inspired by CAD (computer-aided design) approaches currently used in other fields of engineering, was proposed and demonstrated. The solution of the forward problem using a parametric series of structural motifs was first carried out in order to generate a library of drug release profiles associated with each structural motif. The inverse problem was then solved in three steps: first, the combination of basic structural motifs whose superposition provides the closest approximation of the required drug release profile was found by a linear combination of pre-calculated release profiles. In the next step, the final tablet design was constructed and its dissolution curve found computationally. Finally, the proposed design was 3D printed and its dissolution profile was confirmed experimentally. The computational method was based on the numerical solution of drug diffusion in a boundary layer surrounding the tablet, coupled with erosion of the tablet structure encoded by the phase volume function. The tablets were 3D printed by fused deposition modelling (FDM) from filaments produced by hot-melt extrusion. It was found that the drug release profile could be effectively controlled by modifying the tablet porosity. Custom release profiles were obtained by combining multiple porosity regions in the same tablet. The computational method yielded accurate predictions of the drug release rate for both single- and multi-porosity tablets.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20402 - Chemical process engineering

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

AAPS PharmSciTech

ISSN

1530-9932

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

8

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

3414-3424

UT code for WoS article

000452258500010

EID of the result in the Scopus database

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