Mesoporous Silica Particles Used for Amorphous Pharmaceutical Formulations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F18%3A43917285" target="_blank" >RIV/60461373:22340/18:43917285 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/19:43920024
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Mesoporous Silica Particles Used for Amorphous Pharmaceutical Formulations
Original language description
Increasing the dissolution rate of poorly water-soluble active pharmaceutical ingredients (APIs) is a key strategy used for improving their oral bioavailability. One of the formulation approaches is API loading to mesoporous carrier particles, which can increase the dissolution rate through the combination of improved powder wettability and dispersion, higher surface area, and API conversion from crystalline to the amorphous state. From the formulation process point of view, the maximum achievable drug loading is a crucial parameter, which depends on the loading method. Drug loading by sorption from a solution is a technologically attractive approach, since it involves familiar unit operations (mixing, filtration, drying). However, the success of the equilibrium sorption approach depends on the choice of the solvent. In this work we present an experimental study of loading efficiency to mesoporous silica particles, based on a set of APIs combined with different solvents at a range of concentrations.
Czech name
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Czech description
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Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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