Benzoisothiazole-1,1-dioxide-based synthetic receptor for zinc ion recognition in aqueous medium and its interaction with nucleic acids

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F18%3A43917410" target="_blank" >RIV/60461373:22340/18:43917410 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10395950 RIV/60461373:22340/19:43917410 RIV/00064165:_____/19:10395950
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/10610278.2018.1523409?scroll=top&needAccess=true" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/10610278.2018.1523409?scroll=top&needAccess=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10610278.2018.1523409" target="_blank" >10.1080/10610278.2018.1523409</a>

Result language
angličtina
Original language name
Benzoisothiazole-1,1-dioxide-based synthetic receptor for zinc ion recognition in aqueous medium and its interaction with nucleic acids
Original language description
Benzoisothiazole-1,1-dioxide-based synthetic receptor was prepared by two step synthesis in 92 % overall yield. Its applicability for the determination of Zn(II) and interction with nucleic acids was studied by absorption spectroscopy. Obtained data, specifically low limit of detection, 0.15 mu M (R-2=0.9933), showed the high potential of the tested structure motif for the recognition and determination of Zn(II) ions in aqueous media (water:DMSO; 99:1 (/)). Alone receptor displayed orderly strongly RNA affinity. Value of LogK was 6.1 and 4.9 for its complex (1:1) with RNA and DNA, respectively. Nevertheless, in presence of complexed Zn(II) ions, its DNA affinity (represent by K, LogK=5.7) strongly grow to near value obtained for its interaction with RNA. On the other hand, its RNA affinity (LogK=5.9) displayed not significantly change in the presence of complexed one.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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