Silica particles with three levels of porosity for efficient melt amorphisation of drugs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43918383" target="_blank" >RIV/60461373:22340/19:43918383 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.micromeso.2018.07.033" target="_blank" >https://doi.org/10.1016/j.micromeso.2018.07.033</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.micromeso.2018.07.033" target="_blank" >10.1016/j.micromeso.2018.07.033</a>
Alternative languages
Result language
angličtina
Original language name
Silica particles with three levels of porosity for efficient melt amorphisation of drugs
Original language description
Silica particles with a unique multi-level pore structure have been prepared in order to enable efficient melt-in amorphisation of pharmaceutical substances. The dissolution rate of drugs with a low aqueous solubility can be enhanced by their conversion from a crystalline to an amorphous form. In order to avoid spontaneous recrystallisation over time, the amorphous form must be stabilised, in this case by melt-in sorption into a porous carrier. To stabilise the amorphous state, pore diameters not exceeding approximately ten times the equivalent molecular diameter are required. However, since the permeability of porous media scales with the square of the mean pore diameter, carrier particles with pores in the nanometer range suffer from slow melt-in rates. Therefore, silica particles with a novel multi-level porous structure have been proposed in this work. The particles combine a central hollow cavity, a network of conducting macro-pores for enhanced transport rate, and a mesoporous matrix for efficient stabilisation of the amorphous state. The particles were prepared by the hydrolysis of TEOS using a soft-templating method with octylamine. We show that by systematically modulating the hydrolysis rate by the presence of ethanol (a reaction by-product), particles with the desired pore structure, particle size and morphology can be formed. Furthermore, we demonstrate their superior transport properties during melt sorption, high drug loading capacity and the ability to stabilise the amorphous state of a drug.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20402 - Chemical process engineering
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Microporous and mesoporous materials
ISSN
1387-1811
e-ISSN
—
Volume of the periodical
274
Issue of the periodical within the volume
15 January 2019
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
61-69
UT code for WoS article
000450378300008
EID of the result in the Scopus database
2-s2.0-85050633962