Coumarin Troger's base derivatives with cyanine substitution as selective and sensitive fluorescent lysosomal probes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F20%3A43918731" target="_blank" >RIV/60461373:22340/20:43918731 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/20:10411010 RIV/00064165:_____/20:10411010
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0045206819307771" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0045206819307771</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bioorg.2019.103447" target="_blank" >10.1016/j.bioorg.2019.103447</a>
Alternative languages
Result language
angličtina
Original language name
Coumarin Troger's base derivatives with cyanine substitution as selective and sensitive fluorescent lysosomal probes
Original language description
The fluorescent probes based on Troger's base motive with both coumarin and cyanine substitution 11-13 have been synthesized by multi-step synthesis in high overall yields. Intracellular localization of prepared probes have been tested using four different cell lines (HF-P4, BLM, U-2 OS and A-2058). Prepared probes have intensive green and red fluorescence. Co-localization with commercial lysosome specific marker LysoTracker Blue DND 22 has been confirmed that all prepared fluorescent probes labeled lysosomal compartment with high selectivity and probes show excellent brightness at low concentration.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic Chemistry
ISSN
0045-2068
e-ISSN
—
Volume of the periodical
94
Issue of the periodical within the volume
January 2020
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
103447
UT code for WoS article
000505596300099
EID of the result in the Scopus database
2-s2.0-85076201194