Thermodynamic study on complexation of long-chain fatty acid anions with alpha-cyclodextrin in water
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F20%3A43920568" target="_blank" >RIV/60461373:22340/20:43920568 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S016773222031494X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S016773222031494X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molliq.2020.113172" target="_blank" >10.1016/j.molliq.2020.113172</a>
Alternative languages
Result language
angličtina
Original language name
Thermodynamic study on complexation of long-chain fatty acid anions with alpha-cyclodextrin in water
Original language description
The interaction of five long alkyl-chain (>= C-13) fatty acid anions (A(-)) with native alpha-cyclodextrin (alpha-CD) in water was systematically examined using the isothermal titration calorimetry. The A(-) comprised biologically relevant myristate, palmitate, stearate, oleate and linoleate anion. The obtained heat data at several temperatures were treated simultaneously allowing the estimation of a thermodynamically consistent temperature dependence of the equilibrium constant as well as the enthalpy for the sequential formation of the inclusion complexes of 1:1 and 1:2 stoichiometry (A(-):alpha-CD). The formation of 1:1 complex was found remarkably strong with binding constant value up to 2.10(5), the 1:2 complexes are generally by one order of magnitude less stable. Thermodynamic quantities for complexation are discussed in terms of their temperature dependence and structural features such as alkyl chain length and dehydrogenation. Using present data the binding mode of alpha-CD to diacylphospholipids and triacylglycerides bearing identical alkyl moieties was successfully proposed. The detailed knowledge on A(-)/alpha-CD interaction thus allows precise modeling of equilibrium process in complex matrices used as drug delivery systems or cell membrane mimics. (C) 2020 Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Liquids
ISSN
0167-7322
e-ISSN
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Volume of the periodical
311
Issue of the periodical within the volume
01.08.2020
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
113172
UT code for WoS article
000545303600006
EID of the result in the Scopus database
2-s2.0-85085274349