Functionalized hydrogel microparticles prepared by microfluidics and their interaction with tumour marker carbonic anhydrase IX

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F20%3A43920680" target="_blank" >RIV/60461373:22340/20:43920680 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/20:00537848 RIV/68378050:_____/20:00537848
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2020/SM/D0SM01018A#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2020/SM/D0SM01018A#!divAbstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d0sm01018a" target="_blank" >10.1039/d0sm01018a</a>

Result language
angličtina
Original language name
Functionalized hydrogel microparticles prepared by microfluidics and their interaction with tumour marker carbonic anhydrase IX
Original language description
Microfluidics allows precise control of the synthesis of microparticles for specific applications, where size and morphology play an important role. In this work, we have introduced microfluidic chip design with dedicated extraction and gelation sections allowing to prepare hydrogel particles in the size range of a red blood cell. The influence of the extractive channel size, alginate concentration and type of storage media on the final size of the prepared alginate microparticles has been discussed. The second part of the work is dedicated to the surface modification of prepared particles using chitosan, pHPMA and the monoclonal antibody molecule, IgG M75. The specific interaction of the antibody molecule with an antigen domain of carbonic anhydrase IX, the transmembrane tumour protein associated with several types of cancer, is demonstrated by fluorescence imaging and compared to an isotypic antibody molecule. © 2020 The Royal Society of Chemistry.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20402 - Chemical process engineering

Project
<a href="/en/project/GJ17-11851Y" target="_blank" >GJ17-11851Y: Synthesis of biomimetic nanoparticulate materials using a microfluidic platform and investigation of their interaction with cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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