Powder bed packing and API content homogeneity of granules in single drop granule formation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F20%3A43920952" target="_blank" >RIV/60461373:22340/20:43920952 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.powtec.2020.02.039" target="_blank" >https://doi.org/10.1016/j.powtec.2020.02.039</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2020.02.039" target="_blank" >10.1016/j.powtec.2020.02.039</a>

Result language

angličtina

Original language name

Powder bed packing and API content homogeneity of granules in single drop granule formation

Original language description

Single drop granule formation on a static powder bed of pharmaceutical mixtures was studied to investigate the effects of hydrophobicity and primary particle size distribution on the powder bed packing structure and the content homogeneity of active pharmaceutical ingredient (API) in granules formed. The granule formation mechanisms, drop penetration time, granule morphology and internal structure have been previously investigated in a mixture of coarse microcrystalline cellulose (MCC) and fine acetaminophen (APAP). When the APAP amount increased (decreasing particle size and increasing hydrophobicity), drop penetration time increased, formation mechanisms transitioned from Spreading to Tunneling, the granules became smaller in size, and the internal porosity of the granules decreased (Gao et al., 2018). In the current study, single drop granulation on mixtures of MCC and APAP with different particle sizes were investigated for formation mechanisms and granule morphology. Additionally, the powder bed packing structure was characterized by X-ray micro-CT and the API content uniformity was measured by UV–vis spectrometry. It was found that in the mixture made from coarse MCC and fine APAP, the internal structure became heterogeneous and there were dense aggregate regions in both the powder bed and granules from 25% APAP proportion, where the transition from Spreading to Tunneling occurs. The content uniformities of granules from fine powder beds are much more compromised (indicating a discrepancy between the actual value and theoretical value) than those from coarse powder beds. This content discrepancy becomes much larger when the APAP proportion in the powder bed is higher (above 50%). This was previously observed by other researchers (Nguyen et al., 2010) and was attributed to the preferential wetting of the ingredients. It is believed that the primary particle size of the powder bed is more significant than the hydrophobicity in affecting the formation mechanism, granule internal structure, and content uniformity. © 2020 Elsevier B.V.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20401 - Chemical engineering (plants, products)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Powder Technology

ISSN

0032-5910

e-ISSN

—

Volume of the periodical

366

Issue of the periodical within the volume

15 April 2020

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

12-21

UT code for WoS article

000528488000002

EID of the result in the Scopus database

2-s2.0-85080029361