Development of Hot-Melt Extrusion Method to Produce Hydroxyapatite/Polycaprolactone Composite Filaments
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922352" target="_blank" >RIV/60461373:22340/21:43922352 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22350/21:43922352
Result on the web
<a href="https://doi.org/10.1002/adem.202100820" target="_blank" >https://doi.org/10.1002/adem.202100820</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adem.202100820" target="_blank" >10.1002/adem.202100820</a>
Alternative languages
Result language
angličtina
Original language name
Development of Hot-Melt Extrusion Method to Produce Hydroxyapatite/Polycaprolactone Composite Filaments
Original language description
The aim of this work is to develop a single-step process to produce hydroxyapatite/polycaprolactone (HAp/PCL) composite filaments for 3D printing of bone scaffolds by fused deposition modeling (FDM). The HAp/PCL composite filaments are produced by hot-melt extrusion, with direct in situ blending. For practical purposes, the effect of PCL particle size on filament homogeneity and printability is assessed between PCL in powder and pellet form. The effect of HAp content on processing parameters and filament properties is also evaluated. Filament extrudability, homogeneity, and shape consistency improve with increasing HAp content up to a threshold of 40 wt%. Furthermore, an optimal range of the composite melt viscosity for the extrusion process is defined. The produced filaments are successfully 3D printed by FDM and the resulting prototypes show improved compressive modulus and degradation rate with increasing HAp content. A cytocompatibility assay is conducted, which suggests an optimal HAp content to be less than 40 wt% in terms of cell viability, adhesion, and proliferation. The developed method offers several advantages, as it completely avoids the use of toxic solvents and enables the incorporation of very high HAp concentrations, further improving the chances of implementation of FDM for bone tissue regeneration medicine. © 2021 Wiley-VCH GmbH
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20401 - Chemical engineering (plants, products)
Result continuities
Project
<a href="/en/project/TJ02000383" target="_blank" >TJ02000383: Method of drug form production, personalized to fit the needs of a specific patient using mathematical simulation and 3D printing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ADVANCED ENGINEERING MATERIALS
ISSN
1438-1656
e-ISSN
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Volume of the periodical
2100820
Issue of the periodical within the volume
07.09.2021
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
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UT code for WoS article
000695778200001
EID of the result in the Scopus database
2-s2.0-85114852077