Novel method for determination of methoxphenidine and its main metabolite in biological samples

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43924053" target="_blank" >RIV/60461373:22340/22:43924053 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22810/22:43924053

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S2352007822003742" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S2352007822003742</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.toxac.2022.06.302" target="_blank" >10.1016/j.toxac.2022.06.302</a>

Result language

angličtina

Original language name

Novel method for determination of methoxphenidine and its main metabolite in biological samples

Original language description

Methoxphenidine (MXP) is new psychoactive substance belonging to the group of dissociative anesthetics. It appeared on the black market in 2013, and MXP intoxications have been reported with at least three deaths since then. To understanding the mechanism of toxicity and effects of MXP, it is important to know its pharmacological properties (e.g. toxicity, activity on receptors and ADME) and metabolism which may be further exploited to study its mechanism of action in vivo. Metabolism of such compound may be useful not only in toxicological screenings, but together with pharmacokinetic and pharmacodynamic data it enhances the knowledge how these substances may affect the living organism. It is still very little information on the MXP and a method for analysis of biological samples (e.g. brain, liver, lungs and serum) remain to be developed.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

10406 - Analytical chemistry

Project

<a href="/en/project/NU21-04-00307" target="_blank" >NU21-04-00307: Psilocybin versus ketamine – fast acting antidepressant strategies in treatment-resistant depression</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicologie Analytique et Clinique

ISSN

2352-0078

e-ISSN

2352-0086

Volume of the periodical

34

Issue of the periodical within the volume

3

Country of publishing house

FR - FRANCE

Number of pages

2

Pages from-to

"S175"

UT code for WoS article

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EID of the result in the Scopus database

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