Systematic Investigation of Wet-Milling Kinetics and Colloidal Stability of Pharmaceutical Nanocrystals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43924668" target="_blank" >RIV/60461373:22340/22:43924668 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/full/10.1021/acs.cgd.2c00546" target="_blank" >https://pubs.acs.org/doi/full/10.1021/acs.cgd.2c00546</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.cgd.2c00546" target="_blank" >10.1021/acs.cgd.2c00546</a>
Alternative languages
Result language
angličtina
Original language name
Systematic Investigation of Wet-Milling Kinetics and Colloidal Stability of Pharmaceutical Nanocrystals
Original language description
The size reduction of poorly water-soluble crystalline active pharmaceutical ingredients (APIs) to submicrometer dimensions is an alternative to the formation of amorphous solid dispersions when aiming for dissolution rate and bioavailability enhancement. Pharmaceutical nanosuspensions can be produced by wet-stirred media milling, but there is no established classification for assessing the suitability of a given API for this process. The present work reports a systematic study of milling kinetics and colloidal stability of the resulting nanosuspension for 10 APIs (abiraterone acetate, apixaban, atorvastatin, candesartan cilexetil, deferasirox, hydrochlorothiazide, imiquimod, ivacaftor, tadalafil, and telmisartan) in combination with 6 different stabilizer systems that include SDS, Tween 80, HPMC, Poloxamer 188, DPPC, DPPG, MPEG-2000-DMPE, and their combinations. The combination of steric and electrostatic stabilization resulted in colloidally stable nanosuspensions for a broad spectrum of APIs not only for an already established combination of hydroxypropyl methylcellulose and sodium dodecyl sulfate but also for phospholipid-based stabilizers, which have so far not been widely used in the context of nanomilling. A new classification system of API suitability for nanosuspension formation by wet milling has been proposed on the basis of the texture and morphology of the crude crystals. © 2022 American Chemical Society.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20401 - Chemical engineering (plants, products)
Result continuities
Project
<a href="/en/project/GX19-26127X" target="_blank" >GX19-26127X: The robotic nano-pharmacist: Next-generation manufacturing processes for personalised therapeutic agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Crystal Growth & Design
ISSN
1528-7483
e-ISSN
1528-7505
Volume of the periodical
22
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
6928-6940
UT code for WoS article
000878545900001
EID of the result in the Scopus database
2-s2.0-85140984200