What is the role of current mass spectrometry in pharmaceutical analysis?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F23%3A43926969" target="_blank" >RIV/60461373:22340/23:43926969 - isvavai.cz</a>
Result on the web
<a href="https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/mas.21858" target="_blank" >https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/mas.21858</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mas.21858" target="_blank" >10.1002/mas.21858</a>
Alternative languages
Result language
angličtina
Original language name
What is the role of current mass spectrometry in pharmaceutical analysis?
Original language description
The role of mass spectrometry (MS) has become more important in most application domains in recent years. Pharmaceutical analysis is specific due to its stringent regulation procedures, the need for good laboratory/manufacturing practices, and a large number of routine quality control analyses to be carried out. The role of MS is, therefore, very different throughout the whole drug development cycle. While it dominates within the drug discovery and development phase, in routine quality control, the role of MS is minor and indispensable only for selected applications. Moreover, its role is very different in the case of analysis of small molecule pharmaceuticals and biopharmaceuticals. Our review explains the role of current MS in the analysis of both small-molecule chemical drugs and biopharmaceuticals. Important features of MS-based technologies being implemented, method requirements, and related challenges are discussed. The differences in analytical procedures for small molecule pharmaceuticals and biopharmaceuticals are pointed out. While a single method or a small set of methods is usually sufficient for quality control in the case of small molecule pharmaceuticals and MS is often not indispensable, a large panel of methods including extensive use of MS must be used for quality control of biopharmaceuticals. Finally, expected development and future trends are outlined.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mass Spectrometry Reviews
ISSN
0277-7037
e-ISSN
1098-2787
Volume of the periodical
neuveden
Issue of the periodical within the volume
2023
Country of publishing house
US - UNITED STATES
Number of pages
50
Pages from-to
1-50
UT code for WoS article
001037413700001
EID of the result in the Scopus database
2-s2.0-85165913551