In vitro assessment of selenium bioavailability from selenized lactic acid bacteria using a static INFOGEST digestion model and intestinal permeability model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F25%3A43931434" target="_blank" >RIV/60461373:22340/25:43931434 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/25:102118 RIV/26722861:_____/25:N0000002

Result on the web

<a href="https://doi.org/10.1016/j.jtemb.2025.127632" target="_blank" >https://doi.org/10.1016/j.jtemb.2025.127632</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jtemb.2025.127632" target="_blank" >10.1016/j.jtemb.2025.127632</a>

Result language

angličtina

Original language name

In vitro assessment of selenium bioavailability from selenized lactic acid bacteria using a static INFOGEST digestion model and intestinal permeability model

Original language description

Background and objective: Microbial selenium (Se) supplementation is an essential area of biotechnologicalresearch due to differences in the bioavailability and toxicity of different forms of selenium. To date, research hasfocused mainly on the use of selenized yeast. However, in recent years, scientific interest has also increased inother microorganisms, such as lactic acid bacteria (LAB), which have several unique properties that can affect thequality and bioavailability of selenium. LAB, unlike yeast, can also act as probiotics, which may bring additionalhealth benefits related to improving the intestinal microbiota and supporting the health of the gastrointestinaltract.Methods: This study investigates the in vitro bioaccessibility and bioavailability of Se from two lactic acid bacterialstrains, Streptococcus thermophilus CCDM 144 and Enterococcus faecium CCDM 922 A. We evaluated Seaccumulation, speciation, and stability during simulated gastrointestinal digestion and Se permeation through aCaco-2 cell monolayer model.Results: Both strains accumulated Se, metabolizing it predominantly into selenium nanoparticles (SeNPs,64–77 % of total Se), with only a minor fraction (&lt;5 % of total Se) of organic Se species. Experiments revealedthat while organic Se species had high bioavailability (up to 90 %), their bioaccessibility during digestion wasvery low (&lt;0.1 % of total Se). In contrast, SeNPs showed high bioaccessibility (~90 %) and moderate transportefficiency through the intestinal model (16–19 % after 4 hours).Conclusion: These results highlight the potential of SeNPs produced by lactic acid bacteria as a bioaccessible formof Se for dietary supplementation. Further research is required to explore the behavior of SeNPs within thehuman body to fully understand how they can be used safely and effectively in nutrition or other applications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/QK22010186" target="_blank" >QK22010186: Postbiotics, bacterial exopolysaccharides and new oligosaccharides for functional synbiotic fermented products</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

ISSN

0946-672X

e-ISSN

1878-3252

Volume of the periodical

88

Issue of the periodical within the volume

April 2025

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

nestránkováno

UT code for WoS article

001445514400001

EID of the result in the Scopus database

2-s2.0-86000367372