Formulation of hyaluronan grafted with dodecanoic acid as a potential ophthalmic treatment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60917431%3A_____%2F20%3AN0000003" target="_blank" >RIV/60917431:_____/20:N0000003 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.carbpol.2020.116578" target="_blank" >https://doi.org/10.1016/j.carbpol.2020.116578</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2020.116578" target="_blank" >10.1016/j.carbpol.2020.116578</a>

Result language
angličtina
Original language name
Formulation of hyaluronan grafted with dodecanoic acid as a potential ophthalmic treatment
Original language description
This work concerns the chemical modification of medium molecular weight hyaluronan for ophthalmic applications. The synthesis of amphiphilic HA with dodecanoyl moities was carried out under mild aqueous conditions. Perfect control of the degree of substitution was obtained by varying the molar ratio of activated fatty acid used in the reaction feed. Moreover, the preparation of the derivatives was optimized to achieve the desired degree of substitution (DS = 9.0±0.2 %). The prepared hyaluronan derivatives were water-soluble and exhibited self-associating properties (amphiphilicity). The structure of the prepared derivatives was elucidated by NMR spectroscopy, rheology, turbidity, SEC-MALLS, and gas chromatography (GC). The hydrophobic moieties increase the solution viscosity by physical crosslinking. Low concentration of HAC12 is needed to prepare highly viscous solutions with potential use for ophthalmic applications. Amphiphilic HA kept the biocompatibility of hyaluronan. The degree of substitution and Mw of the amphiphilic HA controls the sterilization by filtration. The protection against desiccation was tested using human keratinocytes (HaCaT) cells lines.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/FW01010060" target="_blank" >FW01010060: Research and development of pharmaceutical ingredient to artificial tears for the treatment of dry eye syndrome</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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