Plasma Concentrations and Subcutaneous Adipose Tissue mRNA Expression of Clusterin in Obesity and Type 2 Diabetes Mellitus: the Effect of Short-Term Hyperinsulinemia, Very-Low-Calorie Diet and Bariatric Surgery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F16%3A00000276" target="_blank" >RIV/61383082:_____/16:00000276 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/16:N0000033 RIV/00216208:11110/16:10326999 RIV/00216208:11130/16:10326999 RIV/00064165:_____/16:10326999

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/prepress/933121.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/prepress/933121.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Plasma Concentrations and Subcutaneous Adipose Tissue mRNA Expression of Clusterin in Obesity and Type 2 Diabetes Mellitus: the Effect of Short-Term Hyperinsulinemia, Very-Low-Calorie Diet and Bariatric Surgery

Original language description

Clusterin is a heterodimeric glycoprotein with wide range of functions. To further explore its possible regulatory role in energy homeostasis and in adipose tissue, we measured plasma clusterin and its mRNA expression in subcutaneous adipose tissue (SCAT) of 15 healthy lean women, 15 obese women (OB) and 15 obese women with type 2 diabetes mellitus (T2DM) who underwent a 2-week very low-calorie diet (VLCD), 10 obese women without T2DM who underwent laparoscopic sleeve gastrectomy (LSG) and 8 patients with T2DM, 8 patients with impaired glucose tolerance (IGT) and 8 normoglycemic patients who underwent hyperinsulinemic euglycemic clamp (HEC). VLCD decreased plasma clusterin in OB but not in T2DM patients while LSG and HEC had no effect. Clusterin mRNA expression in SCAT at baseline was increased in OB and T2DM patients compared with controls. Clusterin mRNA expression decreased 6 months after LSG and remained decreased 12 months after LSG. mRNA expression of clusterin was elevated at the end of HEC compared with baseline only in normoglycemic but not in IGT or T2DM patients. In summary, our data suggest a possible local regulatory role for clusterin in the adipose tissue rather than its systemic involvement in the regulation of energy homeostasis.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

12

Pages from-to

481-492

UT code for WoS article

000382115700011

EID of the result in the Scopus database

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