Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F18%3A00000415" target="_blank" >RIV/61383082:_____/18:00000415 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/18:10377412 RIV/00216208:11120/18:43916948 RIV/00216208:11130/18:10377412 RIV/00216208:11150/18:10377412 and 6 more
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pubmed/30064236" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/30064236</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2018_171012N650" target="_blank" >10.4149/neo_2018_171012N650</a>
Alternative languages
Result language
angličtina
Original language name
Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system
Original language description
Aim of the study was to asses the tumor grade prognostic value in the Czech pancreatic cancer patients and to evaluate the accuracy of TNMG prognostic model. Retrospective analysis of 431 pancreatic cancer patients undergoing pancreatic resection in seven Czech oncological centers between 2003 and 2013 was performed. The impact of tumor grade and the accuracy of TNMG prognostic model were evaluated. Lymph node status, tumor size, tumor stage and grade were proved as statistically significant survival predictors. The lower tumor differentiation (grade 3 and 4) was associated with poorer prognosis in all stages (stage I: HR 2.23 [1.14; 4.36, CI 95%] p=0.019, stage II: HR 3.09 [2.01; 4.77, CI 95%] p=0.001, stage III and IV: HR 3.52 [1.73; 7.18, CI 95%] p=0.001). Kaplan-Meier analysis verified statistically significant impact of new TNMG stages on survival after resection for pancreatic cancer (p=0.001). In conclusion, we can state that the tumor grade was confirmed as statistically significant prognostic factor in pancreatic cancer. Its incorporation into the current TNM classification enables more accurate prognosis prediction within particular clinical stages. That is why an inclusion of the grade to the standard TNM classification should be discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/NV16-31314A" target="_blank" >NV16-31314A: Usage of circulating microRNAs for the diagnosis of pancreatic cancer and identification of patients who will not benefit from the surgical resection</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
NEOPLASMA
ISSN
0028-2685
e-ISSN
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Volume of the periodical
65
Issue of the periodical within the volume
4
Country of publishing house
SK - SLOVAKIA
Number of pages
7
Pages from-to
637-643
UT code for WoS article
000440172400019
EID of the result in the Scopus database
2-s2.0-85051260243