Structural volumetry in NPH diagnostics and treatment-future or dead end?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F20%3A00000712" target="_blank" >RIV/61383082:_____/20:00000712 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10406917 RIV/68407700:21730/21:00339318

Result on the web

<a href="https://pubmed.ncbi.nlm.nih.gov/31980974/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/31980974/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10143-020-01245-y" target="_blank" >10.1007/s10143-020-01245-y</a>

Result language

angličtina

Original language name

Structural volumetry in NPH diagnostics and treatment-future or dead end?

Original language description

To assess automated volumetric analysis as a potential presurgical diagnostic tool or as a method to potentially shed light on normal pressure hydrocephalus (NPH) pathophysiology. MRI imaging according to our protocol was performed in 29 NPH patients, 45 non-NPH (but suspected) patients and 15 controls. Twenty patients underwent a second MRI 3 months after ventriculoperitoneal (VP) shunt surgery. All structures relevant to NPH diagnosis were automatically segmented using commercial software. The results were subsequently tested using ANOVA analysis. Significant differences in the volumes of the corpus callosum, left hippocampus, internal globus pallidus, grey and white matter and ventricular volumes were observed between NPH group and healthy controls. However, the differences between NPH and non-NPH groups were non-significant. Three months after, VP shunt insertion decreased ventricular volume was the only clearly significant result (p value 0.0001). Even though a detailed volumetric study shows several significant differences, volumetric analysis as a standalone method does not provide a simple diagnostic biomarker, nor does it shed a light on an unknown NPH aetiology.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NEUROSURGICAL REVIEW

ISSN

0344-5607

e-ISSN

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Volume of the periodical

2020

Issue of the periodical within the volume

Jan

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

1-12

UT code for WoS article

000509141700001

EID of the result in the Scopus database

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