Pathophysiological Characteristics Linking Type 2 Diabetes Mellitus and Colorectal Neoplasia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F21%3A00001057" target="_blank" >RIV/61383082:_____/21:00001057 - isvavai.cz</a>

Alternative codes found

RIV/00023728:_____/21:N0000054 RIV/00216208:11110/21:10433275

Result on the web

<a href="https://pubmed.ncbi.nlm.nih.gov/34062073/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/34062073/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.934631" target="_blank" >10.33549/physiolres.934631</a>

Result language

angličtina

Original language name

Pathophysiological Characteristics Linking Type 2 Diabetes Mellitus and Colorectal Neoplasia

Original language description

A substantial body of literature has provided evidence that type 2 diabetes mellitus (T2DM) and colorectal neoplasia share several common factors. Both diseases are among the leading causes of death worldwide and have an increasing incidence. In addition to usual risk factors such as sedentary lifestyle, obesity, and family history, common pathophysiological mechanisms involved in the development of these diseases have been identified. These include changes in glucose metabolism associated with adipose tissue dysfunction including insulin resistance resulting to hyperinsulinemia and chronic hyperglycemia. In addition to altered glucose metabolism, abdominal obesity has been associated with accented carcinogenesis with chronic subclinical inflammation. An increasing number of studies have recently described the role of the gut microbiota in metabolic diseases including T2DM and the development of colorectal cancer (CRC). Due to the interconnectedness of different pathophysiological processes, it is not entirely clear which factor is crucial in the development of carcinogenesis in patients with T2DM. The aim of this work is to review the current knowledge on the pathophysiological mechanisms of colorectal neoplasia development in individuals with T2DM. Here, we review the potential pathophysiological processes involved in the onset and progression of colorectal neoplasia in patients with T2DM. Uncovering common pathophysiological characteristics is essential for understanding the nature of these diseases and may lead to effective treatment and prevention.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

<a href="/en/project/NV18-08-00246" target="_blank" >NV18-08-00246: Endoscopic full thickness resection versus standard therapy of the colorectal neoplasia — prospective randomized study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

70

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

14

Pages from-to

509-522

UT code for WoS article

000693412000003

EID of the result in the Scopus database

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