Analgesic-muscle relaxant infusion in back pain therapy – technological and clinical aspects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F21%3A00001144" target="_blank" >RIV/61383082:_____/21:00001144 - isvavai.cz</a>

Result on the web

<a href="https://www.medvik.cz/bmc/view.do?gid=1742362" target="_blank" >https://www.medvik.cz/bmc/view.do?gid=1742362</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccsnn2021465" target="_blank" >10.48095/cccsnn2021465</a>

Result language

angličtina

Original language name

Analgesic-muscle relaxant infusion in back pain therapy – technological and clinical aspects

Original language description

Aim: The aim was to clarify the constituents and the method of administration of analgesic-muscle relaxant infusions (AMIs) routinely used in clinical practice, to rationalise individual components in AMIs, and to evaluate the compatibility and stability of the most often used AMI components. Methods: In the form of a questionnaire survey, 15 randomly selected clinical departments were contacted to obtain an overview of the spectrum of AMIs used in the Czech Republic. The rationality of the composition of AMIs was evaluated based on an assessment of the pharmacological and pharmaceutical properties of the drugs and the evidence for their use in back pain therapy. Furthermore, a compatibility and stability study of the two most often used AMIs (mixture No. 1: trimecaine, metamizole, guaifenesin; mixture No. 2: trimecaine, metamizole, magnesium sulfate) was conducted. Results: A large number of diff erent combinations of drugs was found to be used, most often from the group of analgesics, muscle relaxants, corticosteroids, and local anaesthetics. The composition of AMIs proved not to be always completely rational, both from a pharmacotherapeutic (effi cacy, safety, evidence) and technological (compatibility, stability) point of view. The performed technological study then proved the compatibility and stability of the two most frequently used mixtures. Conclusions: The established use of AMIs has a number of signifi cant shortcomings. Therefore, in most cases and for a variety of reasons, oral administration of drugs seems to be more appropriate for the treatment of back pain. Intravenous therapy could thus be reserved for specific situations.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

ISSN

1942-0900

e-ISSN

—

Volume of the periodical

2021

Issue of the periodical within the volume

Oct 4 2021

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

1-7

UT code for WoS article

000762595600003

EID of the result in the Scopus database

—