The role of extracellular vesicle fusion with target cells in triggering systemic inflammation.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F24%3A00001424" target="_blank" >RIV/61383082:_____/24:00001424 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/24:10478730

Result on the web

<a href="https://pubmed.ncbi.nlm.nih.gov/38326335/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/38326335/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-024-45125-1" target="_blank" >10.1038/s41467-024-45125-1</a>

Result language

angličtina

Original language name

The role of extracellular vesicle fusion with target cells in triggering systemic inflammation.

Original language description

Extracellular vesicles (EVs) play a crucial role in intercellular communication by transferring bioactive molecules from donor to recipient cells. As a result, EV fusion leads to the modulation of cellular functions and has an impact on both physiological and pathological processes in the recipient cell. This study explores the impact of EV fusion on cellular responses to inflammatory signaling. Our findings reveal that fusion renders non-responsive cells susceptible to inflammatory signaling, as evidenced by increased NF-κB activation and the release of inflammatory mediators. Syntaxin-binding protein 1 is essential for the merge and activation of intracellular signaling. Subsequent analysis show that EVs transfer their functionally active receptors to target cells, making them prone to an otherwise unresponsive state. EVs in complex with their agonist, require no further stimulation of the target cells to trigger mobilization of NF-κB. While receptor antagonists were unable to inhibit NF-κB activation, blocking of the fusion between EVs and their target cells with heparin mitigated inflammation in mice challenged with EVs.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30502 - Other medical science

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Communications

ISSN

2041-1723

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

17

Pages from-to

1-17

UT code for WoS article

001159313700009

EID of the result in the Scopus database

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