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Tetraphenylporphyrin-cobalt(III) Bis(1.2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F07%3A00081457" target="_blank" >RIV/61388955:_____/07:00081457 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/07:10992 RIV/60461373:22340/07:00020926

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Tetraphenylporphyrin-cobalt(III) Bis(1.2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease

  • Original language description

    Tetraphenylporphyrin conjugates with one (PB1) and four (PB4) cobalt(III)bis(1,2-dicarbollide) substituents were synthesised and the physicochemical and photophysical properties as well as inhibition of HIV-1 protease were described. In methanol, both PB1 and PB4 were monomeric producing the triplet states and singlet oxygen after excitation. The triplet states of PB4 were quickly protonated. Porphyrins exhibited a small decrease of the quantum yields of the singlet oxygen formation (17% for PB4 and 13%for PB1) as compared with 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin. On the contrary, no singlet oxygen was detected in aqueous solutions because of strong aggregation. Light scattering and atomic force microscopy (AFM) measurements documented that the behavior of aggregates in aqueous solutions is fairly complex and depends on pH, concentration, and agign.

  • Czech name

    Tetraphenylporphyrin-cobalt(III) Bis(1,2-dicarbollide) Komplexy: od charakteristik v roztoku až k inhibici HIV Proteázy

  • Czech description

    Tetraphenylporphyrinové komplexy s jednou (PB1) a čtyřmi (PB4) kobalt(III) bis(1,2-dicarbollide) substituenty byly syntetizovány a byly popsány fyzikálně chemické a foto-fyzikální vlastnosti a rovněž inhibice HIV-1 proteázy.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CF - Physical chemistry and theoretical chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Physical Chemistry B

  • ISSN

    1520-6106

  • e-ISSN

  • Volume of the periodical

    111

  • Issue of the periodical within the volume

    -

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    4539-4546

  • UT code for WoS article

  • EID of the result in the Scopus database