Tetraphenylporphyrin-cobalt(III) Bis(1.2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F07%3A00081457" target="_blank" >RIV/61388955:_____/07:00081457 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/07:10992 RIV/60461373:22340/07:00020926
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Tetraphenylporphyrin-cobalt(III) Bis(1.2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease
Original language description
Tetraphenylporphyrin conjugates with one (PB1) and four (PB4) cobalt(III)bis(1,2-dicarbollide) substituents were synthesised and the physicochemical and photophysical properties as well as inhibition of HIV-1 protease were described. In methanol, both PB1 and PB4 were monomeric producing the triplet states and singlet oxygen after excitation. The triplet states of PB4 were quickly protonated. Porphyrins exhibited a small decrease of the quantum yields of the singlet oxygen formation (17% for PB4 and 13%for PB1) as compared with 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin. On the contrary, no singlet oxygen was detected in aqueous solutions because of strong aggregation. Light scattering and atomic force microscopy (AFM) measurements documented that the behavior of aggregates in aqueous solutions is fairly complex and depends on pH, concentration, and agign.
Czech name
Tetraphenylporphyrin-cobalt(III) Bis(1,2-dicarbollide) Komplexy: od charakteristik v roztoku až k inhibici HIV Proteázy
Czech description
Tetraphenylporphyrinové komplexy s jednou (PB1) a čtyřmi (PB4) kobalt(III) bis(1,2-dicarbollide) substituenty byly syntetizovány a byly popsány fyzikálně chemické a foto-fyzikální vlastnosti a rovněž inhibice HIV-1 proteázy.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Physical Chemistry B
ISSN
1520-6106
e-ISSN
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Volume of the periodical
111
Issue of the periodical within the volume
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Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
4539-4546
UT code for WoS article
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EID of the result in the Scopus database
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