Electrochemical quantification of 2,6-diisopropylphenol (propofol)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F11%3A00363717" target="_blank" >RIV/61388955:_____/11:00363717 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.aca.2011.08.003" target="_blank" >http://dx.doi.org/10.1016/j.aca.2011.08.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aca.2011.08.003" target="_blank" >10.1016/j.aca.2011.08.003</a>

Result language
angličtina
Original language name
Electrochemical quantification of 2,6-diisopropylphenol (propofol)
Original language description
2,6-Diisopropylphenol (propofol) is a potent anesthetic drug with fast onset of the anesthetic effect and short recovery time for the patients. Outside of the United States, propofol is widely used in performing target controlled infusion anesthesia. With the long term vision of an electrochemical sensor for in vivo monitoring and feedback controlled dosing of propofol in blood, different alternatives for the electrochemical quantification of propofol using diverse working electrodes and experimental conditions are presented in this contribution. When the electrochemical oxidation of propofol takes place on a glassy carbon working electrode, an electrochemically active film grows on the electrode surface. The reduction current of the film is proportional to the propofol concentration and the accumulation time. Based on these findings a stripping analytical method was developed for the detection of propofol in acidic solutions between 0 and 30 ?M, with a detection limit of 5.50.4 ?M.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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