Protonation of Lipids Impacts the Supramolecular and Biological Properties of Their Self-Assembly
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F11%3A00366666" target="_blank" >RIV/61388955:_____/11:00366666 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/la202439s" target="_blank" >http://dx.doi.org/10.1021/la202439s</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/la202439s" target="_blank" >10.1021/la202439s</a>
Alternative languages
Result language
angličtina
Original language name
Protonation of Lipids Impacts the Supramolecular and Biological Properties of Their Self-Assembly
Original language description
We assessed in this work how a chemical structure difference could influence a supramolecular organization and then its biological properties. In our case study, we considered two amphiphilic lipidic gene vectors. The chemical difference was situated ontheir hydrophilic part which was either a pure neutral thiourea head or a mixture of three thiourea function derivatives, thiourea, iminothiol, and charged iminothiol. This small difference was obtained thanks to the last chemical deprotection conditionsof the polar head hydroxyl groups. Light, neutron, and X-ray scattering techniques have been used to investigate the spatial structure of the liposomes and lipoplexes formed by the lipids. The chemical structure difference impacts the supramolecular assemblies of the lipids and with DNA as shown by fluorescence correlation spectroscopy (FCS), X-ray, and neutron scattering.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Langmuir
ISSN
0743-7463
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
20
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
12336-12345
UT code for WoS article
000295665400013
EID of the result in the Scopus database
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