METRONIDAZOLE RADICAL ANION FORMATION STUDIED BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F11%3A00371757" target="_blank" >RIV/61388955:_____/11:00371757 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1135/cccc2011113" target="_blank" >http://dx.doi.org/10.1135/cccc2011113</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1135/cccc2011113" target="_blank" >10.1135/cccc2011113</a>
Alternative languages
Result language
angličtina
Original language name
METRONIDAZOLE RADICAL ANION FORMATION STUDIED BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY
Original language description
Radiosensitizers belong to the most important class of the cancerostatic drugs. The electrochemical transfer of the first electron to the cytotoxic radiosensitizer Metronidazole (MET) and MET radical anion formation in aprotic medium was studied by meansof electrochemical impedance spectroscopy. The heterogeneous electron transfer rate constant for the first reduction of MET (radical anion production) k0 for the redox couple was determined. Similarly, the diffusion coefficient of MET in dimethylformamide was also calculated by impedance measurements using expression for Warburg coefficient and Warburg plot. Moreover, the equivalent circuit for the redox couple MET/MET? was proposed and its parameters were evaluated using a non-linear least square fitting. Our results, from the electrochemical point of view, also confirm the suitability of MET for the effective treatment of selected types of the cancer.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Collection of Czechoslovak Chemical Communications
ISSN
0010-0765
e-ISSN
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Volume of the periodical
76
Issue of the periodical within the volume
12
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
11
Pages from-to
1607-1617
UT code for WoS article
000299816100013
EID of the result in the Scopus database
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