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Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F13%3A00384535" target="_blank" >RIV/61388955:_____/13:00384535 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1039/C2AN36185J" target="_blank" >http://dx.doi.org/10.1039/C2AN36185J</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1039/C2AN36185J" target="_blank" >10.1039/C2AN36185J</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model

  • Original language description

    Our previous studies have shown that both lung cancer cells and non-malignant lung cells release acetaldehyde in vitro. However, data from other laboratories have produced conflicting results. Furthermore, all these studies have been carried out in 2D models which are less physiological cell growth systems when compared to 3D models. Therefore, we have carried out further work on the release of acetaldehyde by lung cells in 3D collagen hydrogels. Lung cancer cells CALU-1 and non-malignant lung cells NL20 were seeded in these hydrogels at different cell concentrations and the release of acetaldehyde was measured with the Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) technique. The data obtained showed that the amount of acetaldehyde released by both cell types grown in a 3D model is higher when compared to that of the same cells grown in 2D models. More importantly, acetaldehyde from the headspace of lung cancer cells could be measured even at a low cell concentration (105 cells pe

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CF - Physical chemistry and theoretical chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Analyst

  • ISSN

    0003-2654

  • e-ISSN

  • Volume of the periodical

    138

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    5

  • Pages from-to

    91-95

  • UT code for WoS article

    000311823200008

  • EID of the result in the Scopus database