Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F13%3A00384535" target="_blank" >RIV/61388955:_____/13:00384535 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/C2AN36185J" target="_blank" >http://dx.doi.org/10.1039/C2AN36185J</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C2AN36185J" target="_blank" >10.1039/C2AN36185J</a>
Alternative languages
Result language
angličtina
Original language name
Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model
Original language description
Our previous studies have shown that both lung cancer cells and non-malignant lung cells release acetaldehyde in vitro. However, data from other laboratories have produced conflicting results. Furthermore, all these studies have been carried out in 2D models which are less physiological cell growth systems when compared to 3D models. Therefore, we have carried out further work on the release of acetaldehyde by lung cells in 3D collagen hydrogels. Lung cancer cells CALU-1 and non-malignant lung cells NL20 were seeded in these hydrogels at different cell concentrations and the release of acetaldehyde was measured with the Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) technique. The data obtained showed that the amount of acetaldehyde released by both cell types grown in a 3D model is higher when compared to that of the same cells grown in 2D models. More importantly, acetaldehyde from the headspace of lung cancer cells could be measured even at a low cell concentration (105 cells pe
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Analyst
ISSN
0003-2654
e-ISSN
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Volume of the periodical
138
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
91-95
UT code for WoS article
000311823200008
EID of the result in the Scopus database
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