Increase of methanol in exhaled breath quantified by SIFT-MS following aspartame ingestion

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F15%3A00451433" target="_blank" >RIV/61388955:_____/15:00451433 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1088/1752-7155/9/4/047104" target="_blank" >http://dx.doi.org/10.1088/1752-7155/9/4/047104</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/1752-7155/9/4/047104" target="_blank" >10.1088/1752-7155/9/4/047104</a>

Result language

angličtina

Original language name

Increase of methanol in exhaled breath quantified by SIFT-MS following aspartame ingestion

Original language description

Aspartame, methyl-L- ? -aspartyl-L-phenylalaninate, is used worldwide as a sweetener in foods and drinks and is considered to be safe at an acceptable daily intake (ADI) of 40 mg per kg of body weight. This compound is completely hydrolyzed in the gastrointestinal tract to aspartic acid, phenylalanine and methanol, each being toxic at high levels. The objective of the present study was to quantify the volatile methanol component in the exhaled breath of ten healthy volunteers following the ingestion ofa single ADI dose of aspartame. Direct on-line measurements of methanol concentration were made in the mouth and nose breath exhalations using selected ion flow tube mass spectrometry, SIFT-MS, several times before aspartame ingestion in order to establish individual pre-dose (baseline) levels and then during two hours post-ingestion to track their initial increase and subsequent decrease. The results show that breath methanol concentrations increased in all volunteers by 1082 205 parts-

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

<a href="/en/project/GA13-28882S" target="_blank" >GA13-28882S: Excitation, separation and fragmentation of ions by drift fields in SIFT-MS for immediate selective trace gas quantification</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Breath Research

ISSN

1752-7155

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

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UT code for WoS article

000367936100007

EID of the result in the Scopus database

2-s2.0-84953931450