The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F15%3A00452351" target="_blank" >RIV/61388955:_____/15:00452351 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/c4ay02981j" target="_blank" >http://dx.doi.org/10.1039/c4ay02981j</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c4ay02981j" target="_blank" >10.1039/c4ay02981j</a>

Result language

angličtina

Original language name

The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens

Original language description

There is interest in the development of exhaled breath tests for the detection of lower airway infection in children with cystic fibrosis. The first stage of this process is the identification of volatile organic compounds (VOCs) released into the gas phase by CF pathogens that can be used as breath test biomarkers. Selected ion flow tube mass spectrometry (SIFT-MS) is ideally suited to these in vitro studies as it allows simultaneous quantification of multiple VOCs in real time. We review a decade of in vitro experiments using SIFT-MS to analyse the VOCs released by respiratory pathogens. This includes identification and quantification of VOCs and the investigation of the in vitro factors that affect their production. We also report on how our culturemethodology has been refined over the years to better account for variations in bacterial mass. Finally, we discuss how these in vitro findings have been translated into clinical trials and assess possible future applications.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Analytical Methods: advancing methods and applications

ISSN

1759-9660

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

818-824

UT code for WoS article

000349679300001

EID of the result in the Scopus database

2-s2.0-84922473343