Microhydration Prevents Fragmentation of Uracil and Thymine by Low-Energy Electrons

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F16%3A00461876" target="_blank" >RIV/61388955:_____/16:00461876 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1021/acs.jpclett.6b01601" target="_blank" >http://dx.doi.org/10.1021/acs.jpclett.6b01601</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.jpclett.6b01601" target="_blank" >10.1021/acs.jpclett.6b01601</a>

Result language

angličtina

Original language name

Microhydration Prevents Fragmentation of Uracil and Thymine by Low-Energy Electrons

Original language description

When ionizing radiation passes biological matter, a large number of secondary electrons with very low energies (<3 eV) is produced. It is known that such electrons cause an efficient fragmentation of isolated nucleobases via dissociative electron attachment. We present an experimental study of the electron attachment to microhydrated nucleobases. Our novel approach allows significant control over the hydration of molecules studied in the molecular beam. We directly show for the first time that the presence of a few water molecules suppresses the dissociative channel and leads exclusively to formation of intact molecular and hydrated anions. The suppression of fragmentation is ascribed to caging-like effects and fast energy transfer to the solvent. This is in contrast with theoretical prediction that microhydration strongly enhances the fragmentation of nucleobases. The current observation impacts mechanisms of reductive DNA strand breaks proposed to date on the basis of gas-phase experiments.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

<a href="/en/project/GJ16-10995Y" target="_blank" >GJ16-10995Y: Reactions of organometallic complexes relevant for the ion beam cancer therapy</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Physical Chemistry Letters

ISSN

1948-7185

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

AUG 2016

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

3401-3405

UT code for WoS article

000382603300018

EID of the result in the Scopus database

2-s2.0-84984904340