Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00474712" target="_blank" >RIV/61388955:_____/17:00474712 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/17:00474712
Result on the web
<a href="http://dx.doi.org/10.1039/c7cc02208e" target="_blank" >http://dx.doi.org/10.1039/c7cc02208e</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c7cc02208e" target="_blank" >10.1039/c7cc02208e</a>

Result language
angličtina
Original language name
Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes
Original language description
Adsorption of metal cations onto a cellular membrane changes its properties, such as interactions with charged moieties or the propensity for membrane fusion. It is, however, unclear whether cells can regulate ion adsorption and the related functions via locally adjusting their membrane composition. We employed fluorescence techniques and computer simulations to determine how the presence of cholesterol—a key molecule inducing membrane heterogeneity—affects the adsorption of sodium and calcium onto zwitterionic phosphatidylcholine bilayers. We found that the transient adsorption of sodium is dependent on the number of phosphatidylcholine head groups, while the strong surface binding of calcium is determined by the available surface area of the membrane. Cholesterol thus does not affect sodium adsorption and only plays an indirect role in modulating the adsorption of calcium by increasing the total surface area of the membrane. These observations also indicate how lateral lipid heterogeneity can regulate various ion-induced processes including adsorption of peripheral proteins, nanoparticles, and other molecules onto membranes.n
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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