Interaction of procyanidin B-3 with membrane lipids Fluorescence, DSC and FTIR studies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00476373" target="_blank" >RIV/61388955:_____/17:00476373 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbamem.2017.04.026" target="_blank" >http://dx.doi.org/10.1016/j.bbamem.2017.04.026</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbamem.2017.04.026" target="_blank" >10.1016/j.bbamem.2017.04.026</a>
Alternative languages
Result language
angličtina
Original language name
Interaction of procyanidin B-3 with membrane lipids Fluorescence, DSC and FTIR studies
Original language description
Procyanidins, contained in many products abundant in human diet, exhibit high biological activity. However, this activity has not been fully explained at cellular and molecular levels. In this study, we determine the mechanism of interaction of procyanidin B-3 with model lipid membrane. This mechanism was established on the basis of changes induced by B-3 in the physical properties of lipid bilayer. The changes were investigated using steady state and time-resolved fluorescence, DSC, and FTIR. We show that procyanidin B-3 causes changes in the arrangement of the polar heads of lipids, order of their acyl chains and the main lipid phase transition temperature. Furthermore, its presence in the membrane leads to a reduction in membrane dipole potential. Procyanidin B-3 is anchored to membrane via hydrogen bonds formed between its OH groups and the PO2- and C=O groups of lipids, causing changes in both hydrophilic and hydrophobic regions of the membrane. (C) 2017 Published by Elsevier B.V.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochimica Et Biophysica Acta-Biomembranes
ISSN
0005-2736
e-ISSN
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Volume of the periodical
1859
Issue of the periodical within the volume
8
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
1362-1371
UT code for WoS article
000403520800007
EID of the result in the Scopus database
2-s2.0-85019174441