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Tuning phospholipid bilayer permeability by flavonoid apigenin: Electrochemical and atomic force microscopy study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F18%3A00490126" target="_blank" >RIV/61388955:_____/18:00490126 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.jelechem.2018.03.026" target="_blank" >http://dx.doi.org/10.1016/j.jelechem.2018.03.026</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jelechem.2018.03.026" target="_blank" >10.1016/j.jelechem.2018.03.026</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Tuning phospholipid bilayer permeability by flavonoid apigenin: Electrochemical and atomic force microscopy study

  • Original language description

    The ability to tune the permeability of cell membranes might have significant implications in targeted drug delivery applications. In this work we employ electrochemical methods as well as nanolithography realized in the environment of in-situ atomic force microscopy (AFM) to demonstrate that bioactive compound apigenin is capable of altering the permeability of a model phospholipid dipalmitoylphosphatidylcholine bilayer supported by a gold surface. The electron transfer rate through the bilayer was investigated employing [Fe(CN) 6 ] 4− /[Fe(CN) 6 ] 3− redox couple as an electroactive probe. The value of the standard heterogeneous rate constant obtained in the absence of apigenin (k 0 = 6.60∙10 −5 cm·s −1 ) indicates that the electron transfer through the bilayer is rather sluggish confirming its compactness. The addition of apigenin to the system leads to a considerable increase of the electron transfer rate to k 0 = 5.74∙10 −3 cm·s −1 being virtually identical to the value obtained at the bare electrode/electrolyte interface (k 0 = 2.24∙10 −3 cm·s −1 ). This suggests that apigenin induces a significant rearrangement of the supported lipid bilayer increasing thus its permeability. The AFM nanolithography performed in-situ in the presence of apigenin confirmed that the supported lipid bilayer reorganizes itself to a monolayer of molecules laying parallel to the electrode surface.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Electroanalytical Chemistry

  • ISSN

    1572-6657

  • e-ISSN

  • Volume of the periodical

    821

  • Issue of the periodical within the volume

    JUL 2018

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    6

  • Pages from-to

    67-72

  • UT code for WoS article

    000437818600011

  • EID of the result in the Scopus database

    2-s2.0-85044052308