Roughness of Transmembrane Helices Reduces Lipid Membrane Dynamics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F18%3A00497636" target="_blank" >RIV/61388955:_____/18:00497636 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.isci.2018.11.026" target="_blank" >http://dx.doi.org/10.1016/j.isci.2018.11.026</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.isci.2018.11.026" target="_blank" >10.1016/j.isci.2018.11.026</a>
Alternative languages
Result language
angličtina
Original language name
Roughness of Transmembrane Helices Reduces Lipid Membrane Dynamics
Original language description
The dynamics of cellular membranes is primarily determined by lipid species forming a bilayer. Proteins are considered mainly as effector molecules of diverse cellular processes. In addition to large assemblies of proteins, which were found to influence properties of fluid membranes, biological membranes are densely populated by small, highly mobile proteins. However, little is known about the effect of such proteins on the dynamics of membranes. Using synthetic peptides, we demonstrate that transmembrane helices interfere with the mobility of membrane components by trapping lipid acyl chains on their rough surfaces. The effect is more pronounced in the presence of cholesterol, which segregates from the rough surface of helical peptides. This may contribute to the formation or stabilization of membrane heterogeneities. Since roughness is a general property of helical transmembrane segments, our results suggest that, independent of their size or cytoskeleton linkage, integral membrane proteins affect local membrane dynamics and organization.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
iScience
ISSN
2589-0042
e-ISSN
—
Volume of the periodical
10
Issue of the periodical within the volume
DEC 2018
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
87-97
UT code for WoS article
000454331700008
EID of the result in the Scopus database
—