Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00532310" target="_blank" >RIV/61388955:_____/20:00532310 - isvavai.cz</a>
Alternative codes found
RIV/61388980:_____/20:00532310 RIV/00216208:11310/20:10405879
Result on the web
<a href="http://hdl.handle.net/11104/0310832" target="_blank" >http://hdl.handle.net/11104/0310832</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.langmuir.9b03468" target="_blank" >10.1021/acs.langmuir.9b03468</a>
Alternative languages
Result language
angličtina
Original language name
Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties
Original language description
The transport of a photosensitizer to target biological structures followed by the release of singlet oxygen is a critical step in photodynamic therapy. We compared the (photo)physical properties of polystyrene nanoparticles (TPP@PS) of different sizes and self-assembled poly(ethylene glycol)-b-poly(epsilon-caprolactone) core/shell nanoparticles (TPP@PEG-PCL) with different lengths of copolymer blocks, both suitable for the transport of the tetraphenylporphyrin (TPP) photosensitizer. The singlet oxygen was formed inside both nanoparticles after irradiation with visible light. Its kinetics was controlled by the size of TPP@PS, its lifetime (tau(Delta)) increased with increasing nanoparticle size (from 6.5 to 16 mu s) because of hindered diffusion into the external aqueous environment, where it was quickly deactivated. Accordingly, the prolongation of the singlet oxygen-sensitized delayed fluorescence kinetics was found for TPP@PS of high size. The TPP@PEG-PCL self-assemblies allowed for enhanced oxygen diffusion, and the estimated low values of tau(Delta) approximate to 3.7 mu s were independent of the size of building blocks. The delayed fluorescence in oxygen-free conditions originating from triplet-triplet annihilation indicated a high mobility of TPP in the PCL core in comparison with fixed molecules in the PS matrix. Photooxidation of uric acid revealed the highest efficacy for TPP@PS of small sizes, whereas the largest TPP@PS exhibited the lowest activity, and the efficacy of TPP@PEG-PCL remained independent of the sizes of the building blocks.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/GA19-09721S" target="_blank" >GA19-09721S: Light-Responsive Nanofiber Materials and Nanoparticles for Inactivation of Pathogens</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Langmuir
ISSN
0743-7463
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
302-310
UT code for WoS article
000507721200034
EID of the result in the Scopus database
2-s2.0-85077697578