Ruthenium tetrazene complexes bearing glucose moieties on their periphery: Synthesis, characterization, and in vitro cytotoxicity.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00533067" target="_blank" >RIV/61388955:_____/20:00533067 - isvavai.cz</a>
Alternative codes found
RIV/67985858:_____/20:00533067 RIV/00209805:_____/20:00078468 RIV/00216208:11310/20:10420989 RIV/60461373:22310/20:43923763
Result on the web
<a href="http://hdl.handle.net/11104/0311562" target="_blank" >http://hdl.handle.net/11104/0311562</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/aoc.5896" target="_blank" >10.1002/aoc.5896</a>

Result language
angličtina
Original language name
Ruthenium tetrazene complexes bearing glucose moieties on their periphery: Synthesis, characterization, and in vitro cytotoxicity.
Original language description
Ruthenium tetrazene complexes with general formula [Cp*RuCl(1,4-R2N4)] (Cp* = η5-C5Me5), where R = benzyl (1), 2-fluorobenzyl (2), β-D-glucopyr anosyl-unprotected (3a) and acyl-protected (3b–d), 2-acetamido-β-Dglucopyranosyl- unprotected (4a) and acyl-protected (4b–d), propyl-β-D-glucopyranoside-unprotected (5a), and O-acetylated (5b), were synthesized and characterized using nuclear magnetic resonance and electrospray ionization–mass spectrometry. In addition, the molecular structure of 3b was determined using X-ray crystallography. The cytotoxicity of complexes against ovarian (A2780, SK-OV-3) and breast (MDA-MB-231) cancer cell lines and noncancerous cell line HEK-293 was evaluated and compared to cisplatin activity. The carbohydrate-modified complexes bearing acyl-protecting groups exhibited higher efficacy (in low micromolar range) than unprotected ones, where the most active 4d was superior to cisplatin up to five times against all investigated cancer cell lines, however, no significant selectivity was achieved. The complex induced apoptotic cell death at low micromolar concentrations (0.5 μM for A2780 and HEK293, n2 μM for SK-OV-3 and MDA-MB-231).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry

Project
<a href="/en/project/GA17-05838S" target="_blank" >GA17-05838S: Ruthenium-carbohydrate conjugates as cytostatic drugs with an enhanced selectivity to cancer cells</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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