New fluorescent-labelled nanoparticles: synthesis, characterization and interactions with cysteine and homocysteine to evaluate their stability in aqueous solution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00536189" target="_blank" >RIV/61388955:_____/20:00536189 - isvavai.cz</a>
Result on the web
<a href="http://hdl.handle.net/11104/0313999" target="_blank" >http://hdl.handle.net/11104/0313999</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13204-019-01241-9" target="_blank" >10.1007/s13204-019-01241-9</a>

Result language
angličtina
Original language name
New fluorescent-labelled nanoparticles: synthesis, characterization and interactions with cysteine and homocysteine to evaluate their stability in aqueous solution
Original language description
Fluorescent-labelled nanoparticles conjugate the SPR of nanomaterials as well as the fluorescence properties of the capping dye. In this work, we report a study on the synthesis of fluorescent l-tyrosine (l-Tyr) and fluorescein (Fluo)-capped silver nanoparticles (AgNPs) carried out by a fine-tuning of the analytical concentration of the reagents. The AgNPs have been characterized by TEM, UV-Vis, ATR-FTIR, and photoluminescence (PL) spectroscopy and DLS. The adsorption of cysteine and homocysteine on the surface of the nanoparticles has been studied to evaluate their overall evolution in solution and their possible interactions with more complex systems, such as proteins. Opposed to homocysteine, cysteine induces aggregation either of tyrosine- and fluorescein-capped nanoparticles, which are therefore promising systems for the discrimination of biothiols. Furthermore, tyrosine-capped AgNPs, in spite of the better coordinating characteristics of this amino acid with respect to fluorescein, show aggregation abilities with cysteine greater than the fluorescein-capped ones that are unexpectedly more stable and thus less prone to aggregation phenomena.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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