Prebiotic Route to Thymine from Formamide-A Combined Experimental-Theoretical Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F21%3A00542518" target="_blank" >RIV/61388955:_____/21:00542518 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/21:00542518 RIV/62156489:43210/21:43919803 RIV/00216305:26620/21:PU140900
Result on the web
<a href="http://hdl.handle.net/11104/0319915" target="_blank" >http://hdl.handle.net/11104/0319915</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules26082248" target="_blank" >10.3390/molecules26082248</a>
Alternative languages
Result language
angličtina
Original language name
Prebiotic Route to Thymine from Formamide-A Combined Experimental-Theoretical Study
Original language description
Synthesis of RNA nucleobases from formamide is one of the recurring topics of prebiotic chemistry research. Earlier reports suggest that thymine, the substitute for uracil in DNA, may also be synthesized from formamide in the presence of catalysts enabling conversion of formamide to formaldehyde. In the current paper, we show that to a lesser extent conversion of uracil to thymine may occur even in the absence of catalysts. This is enabled by the presence of formic acid in the reaction mixture that forms as the hydrolysis product of formamide. Under the reaction conditions of our study, the disproportionation of formic acid may produce formaldehyde that hydroxymethylates uracil in the first step of the conversion process. The experiments are supplemented by quantum chemical modeling of the reaction pathway, supporting the plausibility of the mechanism suggested by Saladino and coworkers.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
1420-3049
Volume of the periodical
26
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
2248
UT code for WoS article
000644587500001
EID of the result in the Scopus database
2-s2.0-85105179448