Sonochemical Formation of Fluorouracil Nanoparticles: Toward Controlled Drug Delivery from Polymeric Surfaces

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F23%3A00570448" target="_blank" >RIV/61388955:_____/23:00570448 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/23:00570658

Result on the web

<a href="https://hdl.handle.net/11104/0341743" target="_blank" >https://hdl.handle.net/11104/0341743</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsanm.2c05332" target="_blank" >10.1021/acsanm.2c05332</a>

Result language

angličtina

Original language name

Sonochemical Formation of Fluorouracil Nanoparticles: Toward Controlled Drug Delivery from Polymeric Surfaces

Original language description

The biomaterial surface can be essentially upgraded with the therapeutic function by the introduction of controlled, local elution of biologically active molecules. The use of ultrasonic-assisted formation of nanoparticles with controlled size and morphology can be readily utilized for such functionalization. In this study, the synthesis route for the generation of nanoparticles of fluorouracil, the bioactive molecule used in anticancer therapy, was reported. The tandem of experimental (TEM, NTA, ATR-IR) and computational (MD simulations) approaches allowed us to obtain a molecular-level picture of the cavitation bubble interface where the enrichment of fluorouracil molecules takes place. Thanks to the originally developed computational model of cavitation bubbles, we revealed that the bubble interface plays a key role in the prearrangement of drug and solvent molecules, initiating the formation of nanoparticles’ seeds. The proposed mechanism can be applied to other biologically relevant molecules, suggesting that the sonochemical method can be used for the controlled formation of their nanoparticles. The results indicate a feasible way to tailor the surface of polymeric biomaterials via the embedment of nanoparticles, thus having the potential to be used for practical implications as drug delivery systems.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10403 - Physical chemistry

Project

<a href="/en/project/GF22-27317K" target="_blank" >GF22-27317K: Functionalization of biomaterial surfaces by bioactive substances: from fundamentals to application</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Applied Nano Materials

ISSN

2574-0970

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

4271-4278

UT code for WoS article

000957947000001

EID of the result in the Scopus database

2-s2.0-85149447877