Electroreductive Decomplexation and Isomerism of Copper(II) Complexes with Cyclam Ligands for Medical Use
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F24%3A00584313" target="_blank" >RIV/61388955:_____/24:00584313 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10480937
Result on the web
<a href="https://hdl.handle.net/11104/0352244" target="_blank" >https://hdl.handle.net/11104/0352244</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/celc.202300833" target="_blank" >10.1002/celc.202300833</a>
Alternative languages
Result language
angličtina
Original language name
Electroreductive Decomplexation and Isomerism of Copper(II) Complexes with Cyclam Ligands for Medical Use
Original language description
Detailed electrochemical study of copper(II) complexes of cyclam bearing two phosphonate (TE2P), phenolate (TE2PhOH) or carboxylate (TE2A) pendant arms (together with one cross-bridged-cyclam derivative cb-TE2A) was performed using cyclic voltammetry (CV) and polarography. The electrochemical-heterogeneous measurements were accompanied by UV-vis spectra describing the situation in homogeneous phase. Reduction of complexes on mercury electrode in buffered aqueous solutions (pH 2–12) occurs generally as a two-electron process of reductive decomposition. The formed Cu-amalgam can be (e. g. during the anodic scan of CV) reoxidized to Cu(II) cation which undergoes re-complexation resulting in the original complex. This process of a square diagram is manifold repeatable. The results also showed presence of several isomers differing in mutual orientation of substituents on cyclam nitrogen atoms. The primary “kinetic”, pentacoordinated isomers are irreversibly transformed to the stable, hexacoordinated “thermodynamic” ones upon heating. The development of isomerization process was followed electrochemically. The cross-bridged cb-TE2A derivative forms only one isomer which does not change even after heating. The higher stability of the complex manifests itself at pH>8 when the complex is reversibly reduced in one-electron step, formally CuII/CuI, without decomposition.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemElectroChem
ISSN
2196-0216
e-ISSN
2196-0216
Volume of the periodical
11
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
e202300833
UT code for WoS article
001180914400001
EID of the result in the Scopus database
2-s2.0-85186914106