Assessing vitamin E acetate as a proxy for E-cigarette additives in a realistic pulmonary surfactant model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F24%3A00600120" target="_blank" >RIV/61388955:_____/24:00600120 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/24:00599751
Result on the web
<a href="https://hdl.handle.net/11104/0357479" target="_blank" >https://hdl.handle.net/11104/0357479</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-024-75301-8" target="_blank" >10.1038/s41598-024-75301-8</a>
Alternative languages
Result language
angličtina
Original language name
Assessing vitamin E acetate as a proxy for E-cigarette additives in a realistic pulmonary surfactant model
Original language description
Additives in vaping products, such as flavors, preservatives, or thickening agents, are commonly used to enhance user experience. Among these, Vitamin E acetate (VEA) was initially thought to be harmless but has been implicated as the primary cause of e-cigarette or vaping product use-associated lung injury, a serious lung disease. In our study, VEA serves as a proxy for other e-cigarette additives. To explore its harmful effects, we developed an exposure system to subject a pulmonary surfactant (PSurf) model to VEA-rich vapor. Through detailed analysis and atomic-level simulations, we found that VEA tends to cluster into aggregates on the PSurf surface, inducing deformations and weakening its essential elastic properties, critical for respiratory cycle function. Apart from VEA, our experiments also indicate that propylene glycol and vegetable glycerin, widely used in e-liquid mixtures, or their thermal decomposition products, alter surfactant properties. This research provides molecular-level insights into the detrimental impacts of vaping product additives on lung health.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/GA21-19854S" target="_blank" >GA21-19854S: Lipid multilayers in the biological context - Langmuir film microscopy combined with molecular dynamics simulations</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
14
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
23805
UT code for WoS article
001336221700034
EID of the result in the Scopus database
2-s2.0-85206123002