Low-Energy Electron-Induced Dissociation of the Radiosensitizing Agent Sanazole
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F25%3A00635753" target="_blank" >RIV/61388955:_____/25:00635753 - isvavai.cz</a>
Result on the web
<a href="https://hdl.handle.net/11104/0366783" target="_blank" >https://hdl.handle.net/11104/0366783</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cplu.202500120" target="_blank" >10.1002/cplu.202500120</a>
Alternative languages
Result language
angličtina
Original language name
Low-Energy Electron-Induced Dissociation of the Radiosensitizing Agent Sanazole
Original language description
Sanazole is a hypoxic radiosensitizer for which the activation mechanism in cells has been suggested to involve initial reduction. Herein, electron attachment to sanazole under isolated conditions and upon microhydrations is investigated. Employing mass spectrometry supported by quantum chemical calculations, the anion formation mechanism and subsequent fragmentation pathways are examined. In the case of electron attachment to the isolated molecule, predominantly dissociative electron attachment is observed. The most prominent fragment anion, (NTR-yl)- at m/z 113, is suggested to be formed in an exothermic pathway through a single-bond dissociation, whereas other intense fragments require structural reorganization. The limited abundance of the parent anion under isolated conditions is altered upon microhydration conditions since in the latter situation only the (microhydrated) parent anion is observed. This result suggests that hydration closes and/or slows down the dissociation process and indicates that for sanazole, the initial mechanism of action in a reductive cell environment may be similar to that of well-studied nitroimidazole radiosensitizers.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/EH22_008%2F0004558" target="_blank" >EH22_008/0004558: Advanced MUltiscaLe materials for key Enabling Technologies</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemPlusChem
ISSN
2192-6506
e-ISSN
2192-6506
Volume of the periodical
90
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
e2025120
UT code for WoS article
001483209700001
EID of the result in the Scopus database
2-s2.0-105004480111