Synthesis of 3-methyl-3-hydroxy-6-oxo-androstane derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F04%3A00100859" target="_blank" >RIV/61388963:_____/04:00100859 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Synthesis of 3-methyl-3-hydroxy-6-oxo-androstane derivatives
Original language description
3alpha,17beta-Dihydroxy-3beta-methyl-5alpha-androstan-6-one (1) and 3beta,17beta-dihydroxy-3alpha-methyl-5alpha-androstan-6-one (13) were prepared by the reaction of methylmagnesium bromide with the 3-ketosteroids. Structures and configurations in position 3 were determined by NMR spectra. Substitution in the position 6 influences the ratio of the products
Czech name
Syntéza derivátů 3-methyl-3-hydroxy-6-oxo-androstanu
Czech description
Reakcí methyl magnesium bromidu s 3-oxo-steroidy byly připraveny 3alpha,17beta-dihydroxy-3beta-methyl-5alpha-androstan-6-on (1) a 3beta,17beta-dihydroxy-3alpha-methyl-5alpha-androstan-6-on (13). Struktura produktů a konfigurace funkční skupiny v poloze 3byly určeny pomocí NMR spekter. Poměr vznikajících produktů je ovlivněn substitucí v poloze 6

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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