Characterisation of mutated proteinases derived from HIV-positive patients: enzime activity, vitality and inhibition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F04%3A00100873" target="_blank" >RIV/61388963:_____/04:00100873 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Characterisation of mutated proteinases derived from HIV-positive patients: enzime activity, vitality and inhibition
Original language description
In this paper we describe kinetic characterisation of two highly resistant proteases isolated from HIV-positive patients undergoing higly active antiretroviral therapy including protease inhibitors. Kinetic analysis revealed that second-generation PI lopinavir and pseudopeptide inhibitor QF34 retained their subnanomolar potency against both multidrug resistant PR variants
Czech name
Charakterisace mutantních proteas odvozených z HIV-positivních pacientů: enzymová aktivita, vitalita a inhibice
Czech description
V této publikaci popisujeme kinetickou charakterisaci dvou vysoce resistentních proteas isolovaných z HIV-positivních pacientů procházejících vysoce aktivní antiretrovirovou terapií zahrnující proteasové inhibitory. Kinetická analysa prokázala, že lopinavir, inhibitor proteasy druhé generace, a pseudopeptidový inhibitor QF34, si udržují svou subnanomolární aktivitu proti vysoce resistentním variantám proteasy
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/NI6339" target="_blank" >NI6339: Detection and characterisation of HIV-1 mutants resistant to specific therapy with protease inhibitors: evolution of the resistant species and their interactions with other viral proteins</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Collection of Czechoslovak Chemical Communications
ISSN
0010-0765
e-ISSN
—
Volume of the periodical
69
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
11
Pages from-to
703-714
UT code for WoS article
—
EID of the result in the Scopus database
—