Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F04%3A00100884" target="_blank" >RIV/61388963:_____/04:00100884 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds

Original language description

A series of 9-deazapurine-2,6-diamines bearing benzyl groups in positions N2, N6, and 9 was synthetized. Among them, 9, N2,N6-tribenzyl-9-deazapurine-2,6-diamine exhibited the best antiproliferative activity on CCRF-CEM, HL-60, HeLa S3, and L1210 cells:IC50 = 1.9, 2.7, 7.3, and 1.0 micromol/L

Czech name

Syntéza a antiproliferativní účinky 2,6-diamino-9-benzyl-9-deazapurinu a odvozených sloučenin

Czech description

Byla syntetizována série 9-deazapurin-2,6-diaminů nesoucích benzylové skupiny v polohách N2, N6 a 9. Z nich měl nejlepší antiproliferativní aktivitu 9,N2,N6-tribenzyl-9-deazapurin-2,6-diamin na buňkách CCRF-CEM, HL-60, HeLa S3 a L1210: IC50 = 1,9; 2,7; 7,3 a 1,0 mikromol/l

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/1P04OCD13.20" target="_blank" >1P04OCD13.20: New purine nucleoside analogues for therapeutic applications</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic & Medicinal Chemistry

ISSN

0968-0896

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

3187-3195

UT code for WoS article

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EID of the result in the Scopus database

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