Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F06%3A00043419" target="_blank" >RIV/61388963:_____/06:00043419 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling
Original language description
Aspartic proteases secreted by C. albicans (Sap2p), C. tropicalis (Sapt1p), and C. parapsilosis (Sapp1p) were purified and tested for inhibition with a series of peptidomimetic inhibitors with different modifications. Selected compounds inhibited proteases in nanomolar concentration. The sequence alignment of Sap2p, Sapt1p, and Sapp1p and homology modeling of Sapp1p with the crystal structure of Sapt1p and the complex of Sap2p with a peptidomimetic inhibitor identified structural differences, which leadto different susceptibility of individual proteases to inhibition.
Czech name
Srovnání specifit a struktur sekretovaných aspartátových proteas z Candidy parapsilosis, Candidy albicans a Candidy tropicalis pomocí peptidomimetických inhibitorů a homologního modelování
Czech description
Aspartátové proteasy sekretované C. albicans (Sap2p), C. tropicalis (Sapt1p) a C. parapsilosis (Sapp1p) byly purifikovány a testovány se sérií různě modifikovaných peptidomimetických inhibitorů. Vybrané látky inhibovaly proteasy v nanomolárních koncentracích. Srovnání primárních struktur a homologní modelování struktury (Sapp1p) se známými strukturami Sapt1p a komplexu inhibitoru se Sap2p umožnily identifikovat strukturní prvky odpovědné za rozdílnou inhibici jednotlivých proteas.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biological Chemistry
ISSN
1431-6730
e-ISSN
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Volume of the periodical
387
Issue of the periodical within the volume
9
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
1247-1254
UT code for WoS article
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EID of the result in the Scopus database
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