Pyrimidine acyclic nucleotide analogues with aromatic substituents in C-5 position
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F07%3A00084754" target="_blank" >RIV/61388963:_____/07:00084754 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Pyrimidine acyclic nucleotide analogues with aromatic substituents in C-5 position
Original language description
A series of (S)- and (R)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]uracils and cytosines with various aryl or arylmethyl substituents in C-5 position was prepared. (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]-5-phenyluracil and (R)-1-[3-hydroxy-2-(phosphonomethoxy)-propyl]-5-phenylcytosine exhibited activity against some DNA viruses ((HSV-1 and HSV-2, cytomegalovirus and varicella zoster virus), tested in cell cultures. Some of the 5-phenyluracil derivatives possessed inhibitory activity against thymidinephosphorylase from SD-lymphoma.
Czech name
Acyklické analogy nukleotidů s aromatickými substituenty v poloze C-5
Czech description
Byla připravena série (S)- a (R)-1-[3-hydroxy-2-(fosfonomethoxy)propyl]uracilů a cytosinů s různými aryl- a arymethylovými substituenty v poloze C-5. (S)-1-[3-Hydroxy-2-(fosfonomethoxy)propyl]-5-fenyluracil and (R)-1-[3-hydroxy-2-(fosfonomethoxy)propyl]-5-fenylcytosin vykazovaly jistou aktivitu proti DNA virům (HSV-1, HSV-2, cytomegalovirus a varicella zoster virus) na buněčných kulturách. Některé 5-fenyluracilové deriváty vykazovaly inhibiční aktivitu vůči thymidinfosforylase z SD-lymfomu.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Collection of Czechoslovak Chemical Communications
ISSN
0010-0765
e-ISSN
—
Volume of the periodical
72
Issue of the periodical within the volume
7
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
25
Pages from-to
927-951
UT code for WoS article
—
EID of the result in the Scopus database
—