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Bioinformatic analysis and molecular modelling of human ameloblastin suggest a two-domain intrinsically unstructured calcium-binding protein

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F08%3A00315432" target="_blank" >RIV/61388963:_____/08:00315432 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Bioinformatic analysis and molecular modelling of human ameloblastin suggest a two-domain intrinsically unstructured calcium-binding protein

  • Original language description

    Ameloblastin (AMBN) was originally believed to be an enamel-specific extracellular matrix glycoprotein secreted by ameloblasts. Recently, AMBN expression was also detected in developing mesenchymal dental hard tissues, in trauma-induced reparative dentin, and during early craniofacial bone formation. We therefore performed a bio-informatic analysis of AMBN to model ab initio the three-dimensional structure of the molecule. The results suggest that AMBN is a two-domain, intrinsically unstructured protein(IUP). The analysis did not reveal any regions with structural similarity to known receptor-ligand systems, and did not identify any higher-order structures similar to functional regions in other known sequences.

  • Czech name

    Bioinformatická analýza a molekulární modelování lidského ameloblastinu naznačují že jde o dvoudoménový nestruktrurovaný protein za normálních podmínek

  • Czech description

    Ameloblastin byl donedávna považován za enamel-specifický extracelulární matrix glycoprotein sekretováný ameloblasty. V předkládané práci ukazujeme pomocí bioinformatických metod a pomocí metod molekulového modelování že jde s největší pravděpodobností onestrukturovaný, dvoudoménový protein a pravděpodobně hraje významnou roli v sigalizaci a protein-protein interakcích.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CF - Physical chemistry and theoretical chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Oral Sciences

  • ISSN

    0909-8836

  • e-ISSN

  • Volume of the periodical

    116

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    DK - DENMARK

  • Number of pages

    11

  • Pages from-to

  • UT code for WoS article

    000254126200005

  • EID of the result in the Scopus database