Bioinformatic analysis and molecular modelling of human ameloblastin suggest a two-domain intrinsically unstructured calcium-binding protein
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F08%3A00315432" target="_blank" >RIV/61388963:_____/08:00315432 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Bioinformatic analysis and molecular modelling of human ameloblastin suggest a two-domain intrinsically unstructured calcium-binding protein
Original language description
Ameloblastin (AMBN) was originally believed to be an enamel-specific extracellular matrix glycoprotein secreted by ameloblasts. Recently, AMBN expression was also detected in developing mesenchymal dental hard tissues, in trauma-induced reparative dentin, and during early craniofacial bone formation. We therefore performed a bio-informatic analysis of AMBN to model ab initio the three-dimensional structure of the molecule. The results suggest that AMBN is a two-domain, intrinsically unstructured protein(IUP). The analysis did not reveal any regions with structural similarity to known receptor-ligand systems, and did not identify any higher-order structures similar to functional regions in other known sequences.
Czech name
Bioinformatická analýza a molekulární modelování lidského ameloblastinu naznačují že jde o dvoudoménový nestruktrurovaný protein za normálních podmínek
Czech description
Ameloblastin byl donedávna považován za enamel-specifický extracelulární matrix glycoprotein sekretováný ameloblasty. V předkládané práci ukazujeme pomocí bioinformatických metod a pomocí metod molekulového modelování že jde s největší pravděpodobností onestrukturovaný, dvoudoménový protein a pravděpodobně hraje významnou roli v sigalizaci a protein-protein interakcích.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Oral Sciences
ISSN
0909-8836
e-ISSN
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Volume of the periodical
116
Issue of the periodical within the volume
2
Country of publishing house
DK - DENMARK
Number of pages
11
Pages from-to
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UT code for WoS article
000254126200005
EID of the result in the Scopus database
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