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Prolinol-based nucleoside phosphonic acids: new isosteric conformationally flexible nucleotide analogues

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F09%3A00322724" target="_blank" >RIV/61388963:_____/09:00322724 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Prolinol-based nucleoside phosphonic acids: new isosteric conformationally flexible nucleotide analogues

  • Original language description

    Commercially available trans- 4- hydroxy- L- proline has been used as a starting material for the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of pyrrolidine ring. The compounds were testedfot cytotoxic and antiviral properties and subjected to the NMR-based conformational study.

  • Czech name

    Nukleosidfosfonové kyseliny na bázi prolinolu: nová isosterní konformačně flexibilní analoga nukleotidů

  • Czech description

    Komerčně dostupný trans- 4- hydroxy- L- prolin byl použit jako výchozí látka pro syntézu nukleotidových analog na bázi prolinolu, obsahujících N-fosfonomethylovou skupinu vázanou na dusíkový atom pyrrolidinového kruhu. Připravené sloučeniny byly testovány na cytotoxickou a protivirovou aktivitu a jejich konformace v roztoku byla zkoumána pomocí NMR.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2009

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Tetrahedron

  • ISSN

    0040-4020

  • e-ISSN

  • Volume of the periodical

    65

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    15

  • Pages from-to

  • UT code for WoS article

    000262928100019

  • EID of the result in the Scopus database